At Beneficial Microbes and want to know more about NCIMB?

We supply strains and services to support microbiome and probiotic R&D. We undertake strain screening and take part in collaborative projects.

Information you provide will be used in accordance with our privacy policy

Who we work with

NCIMB works with organisations from a diversity of sectors including:

  • Probiotics and live biotherapeutics
  • Agriculture and animal health
  • Cosmetics and personal care
  • Food and beverage
  • Energy
  • Universities and research institutes.

Why choose NCIMB?

  • Great customer service and communication: The feedback we receive from our customers tells us that they value the high levels of customer service that we provide. We work hard to make things easy for you.
  • Strong track record of working with companies and research groups in the microbiome, probiotics and live biotherapeutics sector, supplying strains, offsite storage of biological materials and sequencing services.
  • Well equipped laboratories: Our new purpose built laboratories are well equipped for microbiome work and include containment level 3 laboratory facilities.
  • Our heritage as a culture collection: NCIMB has been preserving, storing and distributing microorganisms for 75 years. Our culture collection includes many microbiome relevant strains, and strains from species on the EFSA qualified presumption of safety list.

What we can work with

We have experience of working with many different sample types including:

  • Faecal samples
  • Bacterial isolates
  • Soils and sediments
  • Water samples and effluents
  • Swabs
  • Biofilm samples

We are always happy to discuss your requirements and advise on sample volumes, storage and transport of samples to us. Get in touch to find out more.

Next generation sequencing services

16S amplicon sequencing/ 16S metagenomics for microbial community analysis

16S amplicon sequencing, also known as 16S metagenomics is an analysis that allows whole bacterial communities to be studied, and has transformed the understanding of environmental microbiology and mankind's relationship with microorganisms. 16S metagenomics analysis provides information on the relative abundance of different groups of bacteria in a microbiome sample. We are equipped with an ACDP category three lab, and our laboratory scientists are experienced in the analysis of a broad variety of samples including faecal samples. If you are new to this kind of analysis you can find out more about what's involved in the service and the results provided in this blog post.

Whole genome sequencing and characterisation of probiotic and live biotherapeutic strains

Live bacteria are used in many animal feed additives and probiotic products and you can use our whole genome sequencing  services to screen strains for antimicrobial resistance genes and virulence factors, as well as to monitor for strain drift over time. At NCIMB, we use the Qiagen CLC Genomics Workbench to analyse sequences obtained. We also offer a package of laboratory tests that assess functional characteristics of candidate probiotic strains. These include mucin adhesion assessment, gastric survival assays and aggregation testing. Our case study gives an example of a package of services that we provided to a customer in the live biotherapeutics sector.

Culture collection

Our culture collection, the National Collection of Industrial, Food and Marine Bacteria, is part of the UK's Biological Resource Network. It's a fantastic collection of thousands of ACDP category 1 & 2 organisms that includes many microbiome-relevant strains.  The collection includes human microbiome strains, including gut commensals, as well as strains isolated from fermented foods and a rich diversity of other source such as soil, waters, plants and the rhizosphere.

The collection also includes many strains from species included on the European Food Safety Authority Qualified Presumption of Safety list. You can browse these strains on this page.

Our standard material transfer agreement is for research use and we also provide licenses for commercial use of our strains.

Enumeration of viable bacteria: viability PCR (PMA-qPCR)

Enumeration of viable microorganisms can be a key requirement for microbiome researchers and companies developing probiotic products, but it is a challenging task.  There has therefore been growing interest in PMA-qPCR, i.e. a qPCR method that can distinguish between living and dead cells, as a way of addressing this challenge.

At NCIMB we carry out projects to support our customers’ process and product development and have experience of undertaking PMA-qPCR as part of customer projects. If you are interested in exploring the use of viability qPCR within a research project, get in touch to find out more.

Storage

At NCIMB we have more than seventy years' experience of preserving and safely storing biological material. An offsite back up can reduce the risk of loss of your important strains and we can tailor a storage package to your needs.

NCIMB is an International Depositary Authority under the Budapest Treaty, and accepts patent deposits of bacteria, fungi, bacteriophage, plasmids, plant seeds and plant cell tissue culture.

Projects

NCIMB undertakes contract research projects for customers in the microbiome and probiotics sectors. We also take part in collaborative research and work with partners to unlock the potential of our culture collection.

Please contact us for more information.
16S metagenomics

16S metagenomics

NCIMB offers 16S metagenomics analysis and our laboratory scientists are experienced in analysis of faecal samples.

16S metagenomics >
Whole genome sequencing

Whole genome sequencing

Characterise strains, monitor for strain drift and compare closely related strains.

Whole genome sequencing >
Preservation

Culture collection

Part of the UK's Biological Resource Network, our culture collection includes microbiome strains, fermented foods strains and more.

Culture Collection >
qPCR testing services

Detect & quantify

Viability qPCR could be a useful technique in microbiome studies and we have experience using it for customer projects.

Quantification of bacteria: qPCR >
Patent Deposit, Preservation and Storage

Storage & Patent Deposit

NCIMB provides a patent deposit service under the Budapest Treaty, as well as preservation and storage services for biological material.

Storage & Patent Deposit >
Microbial Identification Services

Projects

We undertake contract microbiology research projects for customers and take part in collaborative programs.

Contract research & projects >